Background: The effectiveness of creatine in treating Parkinson�s disease (PD) has not been conclusively\ndetermined. Therefore, we performed a meta-analysis to address this issue.\nMethods: The Cochrane Central Register of Controlled Trials, PUBMED, EMBASE, and other databases were\nsearched, and outcomes measured by the Total Unified Parkinson�s Disease Rating Scale (UPDRS) and the Schwab &\nEngland Scale were analyzed.\nResults: Five randomized controlled trials (RCTs) were selected, and 1339 participants were included in the analysis.\nThere were no significant differences between the control and treatment groups in the total, mental, activities of daily\nliving (ADL), or motor UPDRS scores, but an improvement in Schwab & England Scale scores was observed.\nConclusions: Creatine has no observed benefit in PD patients, although more correlated studies are still needed.
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